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Chemical deuteration involves deuterating whole molecules or building blocks for the synthesis of a desired molecule by exposing them to heavy water (deuterium oxide) at high temperatures and pressures in the presence of a catalyst. If required, compounds can then be synthesised from the deuterated building blocks using organic chemistry techniques.
Publications by ANSTO's National Deuteration Facility.
The National Deuteration Facility offers the facilities and expertise to produce molecules where all or part of the molecular hydrogen is replaced with deuterium. This enables complex investigations of the relationship between the structure of molecules and their function using neutron scattering and other techniques.
The National Deuteration Facility offers access to deuterated molecules prepared by both in vivo biodeuteration and chemical deuteration techniques.
Links to all previous news and case studies published by the National Deuteration Facility
Deuterated rasiotracer subject of poster
The National Deuteration Facility is providing deuterated cholesterol, an essential ingredient in lipid nanoparticles for the delivery of vaccines using mRNA, to academic and industry partners.
Scientists at ANSTO's National Deuteration Facility.
A large collaboration of European investigators gained insights into how the SARS-CoV-2 spike protein (S protein) impacts with lipid metabolism in the body with implications for COVID-19 infection and mRNA vaccination.
The Australian Centre for Neutron Scattering and National Deuteration Facility have announced the first recipients of the Neutron and Deuteration Impact Awards.
Voucher scheme accelerating medical research
ANSTO's facilities in Sydney include access to neutron beam instruments, X-ray and infrared instruments, biological and chemical deuteration, accelerators, and an array of other capabilities and techniques.